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The World in Medicine
September 9, 1998

Neurofibromatosis Clue

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JAMA. 1998;280(10):873. doi:10.1001/jama.280.10.873-JWM80006-5-1

Researchers in Germany have come up with a molecular explanation for the proliferation of tumors in patients with von Recklinghausen neurofibromatosis.

In the August 3 issue of the European Molecular Biology Organization's EMBO Journal, the researchers identified for the first time a functional region of the huge neurofibromin protein that is linked with development of the disease. They reported that a segment comprising about 10% of the 3000 amino acids that make up neurofibromin acts as a down regulator of Ras, a protein intimately associated with cell growth and widely implicated in the development of cancer.

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