Harriet S.MeyerMD, Contributing EditorJonathan D.EldredgeMLS, PhD, Journal Review EditorRobertHoganMD, adviser for new media
Copyright 1999 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1999American Medical Association
requirements: pentium 90, 33 MB, SVGA monitor with 800 × 600 pixels and 256 colors, CD-ROM drive (required for installation), 32-bit Windows operating systems (Windows 95, 98, NT 3.51, or 4.0), 16 MB RAM for 95, 20 MB for NT 3.51, and 32 for NT 4.0, Microsoft Visual C++ (4.2 for NT 3.51 or 5.0 for NT 4.0 or 95) to create user-defined model components and to link to SAS, PC SAS version 6.12 or later installed as an OLE automation server; $7500, special educational pricing available; Mountain View, Calif, Pharsight Corp, 888-708-7444, email@example.com.
Introduction: drug development is bigger and bigger business. The average cost of a compound is now $300 million, and the clinical trials to get the drug approved average about $100 million in cost. Most academicians see only a part of the process, and practicing clinicians see only the tail spout.
Outside medicine, industrial organizations increasingly turn to simulation to select courses of action. Aerospace and financial companies are especially known to do this. The Pharsight Corporation is gambling that this approach applies to pharmaceutical development as well as it does to the design and marketing of new airplanes. Their gamble may pay off: in the past year, they have absorbed other companies doing similar activity and are poised to be the leaders in the field of computer-assisted trial design (CATD).
Trial DesignPharsight Trial Designer. JAMA. 1999;281(10):955-957. doi:10.1001/jama.281.10.955-JBK0310-5-1