Relatively inexpensive antibiotics (such as amoxicillin or folate inhibitors) are as effective as newer and more costly antibiotics (such as third-generation cephalosporins) in treating uncomplicated acute bacterial sinusitis, according to a new report sponsored by the Agency for Health Care Policy and Research (AHCPR).
Moreover, while more patients were cured, and cured earlier when treated with antibiotics rather than placebo, about two thirds of the patients receiving placebo recovered without antibiotics, the report noted. The report also found that using x-rays or other diagnostic procedures is not a cost-effective initial strategy for evaluating patients with uncomplicated sinusitis.
Stephenson J. . . . and Sinusitis "Bugs". JAMA. 1999;281(15):1368. doi:10.1001/jama.281.15.1368-JHA90002-4-1