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Newer antidepressant drugs, selective serotonin reuptake inhibitors (SSRIs), are as effective in treating depression as older-generation antidepressants, such as tricyclics, according to a new evidence report prepared for the Agency for Health Care Policy and Research (AHCPR) by the San Antonio (Tex) Evidence-based Practice Center. The researchers, who reviewed relevant literature on medications for treating depression, said that older and newer antidepressant drugs also have similar dropout rates because of adverse effects.
Stephenson J. Treating Depression. JAMA. 1999;281(19):1784. doi:10.1001/jama.281.19.1784-JHA90003-3-1