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Health Agencies Update
May 19, 1999

Treating Depression

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JAMA. 1999;281(19):1784. doi:10.1001/jama.281.19.1784-JHA90003-3-1

Newer antidepressant drugs, selective serotonin reuptake inhibitors (SSRIs), are as effective in treating depression as older-generation antidepressants, such as tricyclics, according to a new evidence report prepared for the Agency for Health Care Policy and Research (AHCPR) by the San Antonio (Tex) Evidence-based Practice Center. The researchers, who reviewed relevant literature on medications for treating depression, said that older and newer antidepressant drugs also have similar dropout rates because of adverse effects.

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