Newer antidepressant drugs, selective serotonin reuptake inhibitors (SSRIs), are as effective in treating depression as older-generation antidepressants, such as tricyclics, according to a new evidence report prepared for the Agency for Health Care Policy and Research (AHCPR) by the San Antonio (Tex) Evidence-based Practice Center. The researchers, who reviewed relevant literature on medications for treating depression, said that older and newer antidepressant drugs also have similar dropout rates because of adverse effects.
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