To the Editor: In his Clinical Crossroads discussion of a 51-year-old woman with bipolar disorder who wants to quit smoking, Dr Schroeder1 indicated that bupropion should be considered for smokers with chronic depression because it may benefit the depression as well as help with smoking cessation. However, this point is controversial in patients with bipolar disorders because of questions about efficacy and the risk of precipitating mania.
Dervaux A, Laqueille X. Antidepressant Treatment and Smoking Cessation in Bipolar Disorder. JAMA. 2009;301(20):2093. doi:10.1001/jama.2009.705