The FDA has approved celecoxib (Celebrex, GD Searle, Skokie, Ill) for relief of the signs and symptoms of osteoarthritis and for relief of the signs and symptoms of rheumatoid arthritis in adults. Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) whose mechanism of action is believed to be due to inhibition of prostaglandin synthesis, primarily via inhibition of cyclooxygenase-2 (COX-2). At therapeutic doses in humans, it does not appear to inhibit COX-1 (believed by many to be important in the gastrointestinal system).
Nightingale SL. Celecoxib for Arthritis. JAMA. 1999;281(9):786. doi:10.1001/jama.281.9.786-JFD90001-2-1