Views 1,099
Citations 0
Comment & Response
March 12, 2014

Mortality in Patients With Hypovolemic Shock Treated With Colloids or Crystalloids

Author Affiliations
  • 1Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia
  • 2George Institute for Global Health, University of Sydney, Sydney, Australia

Copyright 2014 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2014;311(10):1067-1068. doi:10.1001/jama.2014.833

To the Editor The CRISTAL trial1 requires scrutiny because its results contradict other high-quality evidence.2 The CRISTAL trial was stopped for futility based on no difference in 28-day mortality, but reported numerically lower mortality for the colloids group. However, eFigure 1 in the article suggests lower mortality in the crystalloids group when the trial was stopped. eFigure 2 shows a sudden increase in probability of death at 28 days in both groups; this indicates either censoring (suggesting the denominator for 90-day mortality was wrong) or an unexplained and puzzling cluster of deaths on day 28 resulting in the mortality difference at 90 days.

First Page Preview View Large
First page PDF preview
First page PDF preview