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Comment & Response
March 12, 2014

Stem Cells and Cardiovascular Drug Development—Reply

Author Affiliations
  • 1Stanford University School of Medicine, Stanford, California
JAMA. 2014;311(10):1070-1071. doi:10.1001/jama.2014.634

In Reply Drs Rao and Dlouhy mention several valid points regarding the bottlenecks of iPSC derivation and suggest that direct reprogramming to induced cardiomyocytes (iCMs) may be a more cost-effective, efficient, and safe alternative. Transdifferentiation to iCMs presents both advantages and disadvantages compared with the use of iPSC-derived cardiomyocytes. We think that both of these methods offer significant potential for the clinical treatment of cardiac disease in addition to cardiovascular drug discovery.

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