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News From the Centers for Disease Control and Prevention
March 12, 2014

Compounded Medications Linked With Eye Infection Outbreaks

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Copyright 2014 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2014;311(10):1007. doi:10.1001/jama.2014.1622

Public health investigators traced the largest US outbreak of fungal endophthalmitis to environmental mold that contaminated medications produced by a Florida compounding pharmacy. The infections also represent one of the largest outbreaks in the United States attributed to a contaminated compounded medication.

The investigation began in March 2012 after the California Department of Public Health received reports that 9 patients developed fungal endophthalmitis after they had undergone pars plana vitrectomies at the same Los Angeles County ambulatory surgical center. Records showed that all 9 patients had been exposed to a single lot of Brilliant Blue G dye (BBG), which is used to stain epiretinal membranes during vitrectomies.

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