To the Editor: The Safety and Efficacy of Dexmedetomidine Compared With Midazolam (SEDCOM) trial by Dr Riker and colleagues1 compared dexmedetomidine with midazolam as primary sedative medications for mechanically ventilated patients in the intensive care unit (ICU). Patients receiving dexmedetomidine had a lower prevalence of delirium and were extubated almost 2 days earlier than the midazolam group. We believe the safety data from the trial suggest that clinicians should be concerned about using dexmedetomidine in the study's primary patient population, those with severe sepsis.
DePriest J, Gonzalez L. Comparing Dexmedetomidine With Midazolam for Sedation of Patients in the ICU. JAMA. 2009;301(23):2439-2442. doi:10.1001/jama.2009.836