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June 17, 2009

Comparing Dexmedetomidine With Midazolam for Sedation of Patients in the ICU

JAMA. 2009;301(23):2439-2442. doi:10.1001/jama.2009.839

To the Editor: Dr Riker and colleagues1 compared midazolam vs dexmedetomidine for sedation in ICU patients. In Figure 1, of the initial 420 patients who provided consent, 1 patient was excluded for “drug dependence.” However, since the initial study protocol did not state that patients with drug dependence were to be excluded, it was unclear why this occurred.

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