To the Editor: Dr Riker and colleagues1 compared midazolam vs dexmedetomidine for sedation in ICU patients. In Figure 1, of the initial 420 patients who provided consent, 1 patient was excluded for “drug dependence.” However, since the initial study protocol did not state that patients with drug dependence were to be excluded, it was unclear why this occurred.
Gupta A, Lee D, Su M. Comparing Dexmedetomidine With Midazolam for Sedation of Patients in the ICU. JAMA. 2009;301(23):2439-2442. doi:10.1001/jama.2009.839