Author Affiliations: Hospital Medicine Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.
The medical literature is expanding rapidly, with thousands of new studies published each year. Increasingly, clinicians and scientists rely on rigorous syntheses of the scientific literature, such as high-quality systematic reviews and meta-analyses, which the Oxford Centre for Evidence-Based Medicine considers the highest level of scientific evidence available.1 However, systematic reviews and meta-analyses are typically based on the published literature, which is known to be biased,2- 4 creating an important question: can we trust the highest level of evidence available in MEDLINE?
O’Connor AB. The Need for Improved Access to FDA Reviews. JAMA. 2009;302(2):191-193. doi:10.1001/jama.2009.973