Harriet S.MeyerMD, Contributing EditorJonathan D.EldredgeMLS, PhD, Journal Review EditorRobertHoganMD, adviser for new media
A century ago, Cushing revolutionized brain tumor surgery. Although he rarely achieved total removal, he made such operations safe, with mortality under 10%. Now, a second revolution presses on toward total excision: after magnetic resonance imaging (MRI) localization, image-guided surgery is achieving gross total resection of tumors—even gliomas—with safety and increasing frequency. Experimental laboratories have generated dozens of adjunct therapies to annihilate microscopic tumor remnants. The rapidly increasing sophistication of the armamentarium makes cure of glioma a realistic possibility.
GliomasThe Gliomas. JAMA. 1999;282(11):1096. doi:10.1001/jama.282.11.1096-JBK0915-5-1