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Health Agencies Update
October 20, 1999

Exploring Cancer Metastasis

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Copyright 1999 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1999American Medical Association

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JAMA. 1999;282(15):1415. doi:10.1001/jama.282.15.1415-JHA90008-4-1

A research team led by scientists at the National Institute of Dental and Craniofacial Research reports in the September 1 issue of Cancer Research that a protein in bone appears to act as an attractant for prostate cancer cells.

The researchers found that osteonectin, a protein thought to be involved in bone mineralization, not only attracts prostate cancer cells but also stimulates them to become invasive. They also discovered that the attractive ability of a bone extract could be eliminated by treating it with an antibody that specifically binds to osteonectin.

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