A research team led by scientists at the National Institute of Dental and Craniofacial Research reports in the September 1 issue of Cancer Research that a protein in bone appears to act as an attractant for prostate cancer cells.
The researchers found that osteonectin, a protein thought to be involved in bone mineralization, not only attracts prostate cancer cells but also stimulates them to become invasive. They also discovered that the attractive ability of a bone extract could be eliminated by treating it with an antibody that specifically binds to osteonectin.
Stephenson J. Exploring Cancer Metastasis. JAMA. 1999;282(15):1415. doi:10.1001/jama.282.15.1415-JHA90008-4-1