The FDA has approved Synercid (Rhone-Poulenc Rorer, Collegeville, Pa), the first antimicrobial drug to treat infections associated with vancomycin-resistant Enterococcus faecium (VREF) bacteremia. Synercid, a combination of quinupristin and dalfopristin, also received approval for the treatment of complicated skin and skin structure (SST) infections (such as cellulitis/erysipelas, postoperative infections, and traumatic wound infections) caused by methicillin-susceptible Staphylococcus aureus and Streptococcus pyogenes.
Henney JE. First Antibacterial for VREF. JAMA. 1999;282(17):1613. doi:10.1001/jama.282.17.1613-JFD90009-2-1