Citations 0
The World in Medicine
December 8, 1999

Genetics and Coronary Spasm

Author Affiliations

Not Available


Copyright 1999 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1999American Medical Association

Not Available

JAMA. 1999;282(22):2111. doi:10.1001/jama.282.22.2111-JWM90010-2-1

Researchers in Japan have uncovered the genetic underpinning of coronary artery spasm, a condition responsible for chest pain and, in severe cases, myocardial infarction.

In a study of 201 patients with coronary artery spasm and 345 healthy controls, researchers from Kumamoto University discovered that a mutation in the endothelial nitric oxide synthase (eNOS) gene was the most predictive risk factor, followed by cigarette smoking, for coronary artery spasm. The eNOS gene controls nitric oxide production in the epithelium of blood vessel walls. Nitric oxide is a key chemical in regulating blood vessel dilation.

First Page Preview View Large
First page PDF preview
First page PDF preview