Seattle—Researchers are developing new animal models of pathogenesis to gain greater insight into the underlying mechanisms of chronic neurodegeneration and to test new drug treatments for Parkinson disease (PD).
One such model, presented by J. Timothy Greenamyre, MD, PhD, of Emory University, at a conference on the Etiology, Pathogenesis, and Treatment of Parkinson's Disease and Other Movement Disorders, held here in October, appears to reproduce the neurochemical, neuropathological, and behavioral features of the disease through chronically exposing laboratory rats to the pesticide rotenone.
Friedrich MJ. Pesticide Study Aids Parkinson Research. JAMA. 1999;282(23):2200. doi:10.1001/jama.282.23.2200-JMN1215-4-1