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The World in Medicine
March 8, 2000

Please Pass the Margarine

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JAMA. 2000;283(10):1282. doi:10.1001/jama.283.10.1282-JWM00001-2-1

Researchers in Finland have discovered that a specially developed margarine can reduce blood cholesterol levels in children who have an inherited risk for early heart disease.

Children in the study had heterozygous familial hypercholesterolemia (FH), a genetic disease in which low-density lipoprotein (LDL) cholesterol cannot be properly eliminated from the body. Atherosclerosis should be treated early in individuals with FH, but bile acid–binding resins commonly used in treatment have unpleasant adverse effects that decrease compliance in children.

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