[Skip to Content]
[Skip to Content Landing]
Citations 0
Letters
March NaN, 2000

Chronobiology of Recombinant Leptin Therapy—Reply

Author Affiliations
 

Phil B.FontanarosaMD, Deputy EditorStephen J.LurieMD, PhD, Fishbein Fellow

 

Not Available

JAMA. 2000;283(12):1567-1568. doi:10.1001/jama.283.12.1567-JLT0322-14-1

In Reply: Dr Frühbeck and colleagues raise several important points related to leptin physiology as it applies to our study. Our evaluation of weight loss was across the dose range and not just at the higher leptin dose. Also, our study was designed to examine pharmacologic rather than biological effects of leptin. Pharmacokinetic results show that the amount of leptin administered far exceeded endogenous secretion. Additional studies have been conducted, as suggested by Frühbeck et al, evaluating morning vs evening leptin administration and the analysis of these results is ongoing.

First Page Preview View Large
First page PDF preview
First page PDF preview
×