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JAMA 100 Years Ago
June 7, 2000

Methylene Blue in Grave Malaria Cachexia.

Author Affiliations

JenniferReiling, Editorial Assistant

JAMA. 2000;283(21):2765. doi:10.1001/jama.283.21.2765-JJY00015-4-1

Cardamatis, of Athens, writes to the Progrés Médical that he has found methylene blue very effective in the early stages of severe malarial cachexia in cases rebellious to quinin. He recommends it warmly for its action not only on the malarial plasmodium, but also on the consequences of the infection, through its regulating effect on the functions of the kidneys. A typical observation is described, of a child affected with la grippe, traumatic perisplenitis and dysenteriform diarrhea, leading to revival of a light, malarial infection contracted during a stay of a few days in a malarial region a year before, which terminated in grave malarial cachexia and gangrene. The prompt efficacy of methylene blue combined with tepid hydrotherapy was thoroughly attested in this and in other cases in his experience.

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