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Books, Journals, New Media
September 27, 2000

HemochromatosisHemochromatosis: Genetics, Pathophysiology, Diagnosis, and Treatment

Author Affiliations

Harriet S.MeyerMD, Contributing EditorDavid H.MorseMS, Journal Review EditorRobertHoganMD, adviser for new media


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Copyright 2000 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2000American Medical Association


edited by James C. Barton and Corwin Q. Edwards, 600 pp, with illus, $215, ISBN 0-521-59380-8, New York, NY, Cambridge University Press, 2000.

JAMA. 2000;284(12):1581. doi:10.1001/jama.284.12.1581-JBK0927-3-1

Few busy physicians are aware that a patient with hemochromatosis passes through their offices about every two weeks. And yet, observations published over the past decade and confirmed by the recent discovery of the HFE gene make that startling calculation incontestable: the prevalence of the homozygous genotype for hemochromatosis is 4 per 1000 Americans. Hemochromatosis is the most common genetic disease in the United States. Indeed, several medical futurists have predicted that hemochromatosis will be the cholesterol of the 21st century. All this is a long way from our vague recollection of some never-seen triad of bronze diabetes and cirrhosis.

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