The FDA has approved labeling for a new use for the antihypertensive drug ramipril (Altace, Aventis Pharmaceuticals, Kansas City, Mo), an ACE inhibitor, to reduce the risk of myocardial infarction, stroke, or death from cardiovascular causes.
The new indication is limited to patients 55 years or older who are at high risk for developing a major cardiovascular event because of history of coronary artery disease, stroke, peripheral vascular disease, or type 1 or 2 diabetes that is accompanied by at least one other cardiovascular risk factor, such as hypertension, cigarette smoking, elevated total cholesterol levels, low HDL level, or proteinuria. Ramipril can be used in addition to other treatment.
Henney JE. Preventive Use for Ramipril. JAMA. 2000;284(21):2711. doi:10.1001/jama.284.21.2711-JFD00010-3-1