The FDA has approved Trizivir (Glaxo Wellcome, Research Triangle Park, NC), alone or in combination with other antiretroviral agents, for the treatment of HIV-1 infection in adults and adolescents. Trizivir is a combination of three synthetic nucleoside analogs previously approved by the FDA: abacavir sulfate (Ziagen), lamivudine (Epivir), and zidovudine (Retrovir). One Trizivir tablet is bioequivalent to one tablet each of Ziagen (300 mg), Epivir (150 mg), and Retrovir (300 mg). As a fixed-dosage tablet, Trizivir is not recommended for treatment of patients who weigh less than 90 lb.
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