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August 12, 2009

Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus

JAMA. 2009;302(6):624-625. doi:10.1001/jama.2009.1099

To the Editor: The study by Dr Couri and colleagues1 provided follow-up of a preliminary report.2 The current article included 23 patients, with a mean follow-up that was increased from 18.8 to 29.8 months.

After removing from the analysis 3 patients who were not able to have insulin suspended, the authors stated that 12 of 20 patients (60%) remained insulin-free for a mean of 31 months after transplantation. We consider this a biased analysis; including the 3 nonresponders would have indicated a success rate of 12 of 23 (52.1%).

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