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Health Agencies Update
April 18, 2001

Eosinophils and Food Allergy

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JAMA. 2001;285(15):1952. doi:10.1001/jama.285.15.1952-JHA10003-2-1

Investigators have found a new candidate for the cause of food allergies: eosinophils. Until now, it was unknown whether these components of the immune system caused damage or were simply innocent bystanders during food allergies.

In research supported by the National Institute of Allergy and Infectious Diseases (NIAID), Mark Rothenberg, MD, PhD, of Children's Medical Center in Cincinnati, directed a team in developing a mouse model of allergy. The animals developed inflamed digestive tracts, became ill, and lost weight, similar to humans with eosinophilic gastrointestinal inflammation.

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