Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2001American Medical Association
Banff, Alberta—Researchers believe that new findings from animal studies shed light on what caused the devastating immune system reaction that resulted in the first known death of a participant in a gene-therapy trial.
The evidence indicates that the protein coat of the vector—a disarmed adenovirus used to ferry a normal gene into the patient's liver cells—triggered the innate immune response featuring a massive release of cytokines, said James Wilson, MD, PhD, director of the University of Pennsylvania's Institute for Human Gene Therapy.
Stephenson J. Studies Illuminate Cause of Fatal Reaction in Gene-Therapy Trial. JAMA. 2001;285(20):2570. doi:10.1001/jama.285.20.2570-JMN0523-3-1