[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Citations 0
Quick Uptakes
December 26, 2001

COX-2 Inhibitors and Ligaments

Author Affiliations

Not Available

Not Available

JAMA. 2001;286(24):3071. doi:10.1001/jama.286.24.3071-JQU10011-3-1

Cyclooxygenase 2–specific (COX-2) inhibitors, widely prescribed for arthritis symptoms, may impair ligament healing associated with sprains, report researchers at the University of North Carolina at Chapel Hill School of Medicine. Unlike earlier generations of nonsteroidal anti-inflammatory drugs, which have been found to promote ligament healing, the COX-2 inhibitors apparently do not, said Lawrence E. Dahners, MD, professor of orthopedics.

The study in rats involved an experimental model for an acute injury of the medial collateral ligament, in humans the most common site of knee sprains. Postoperatively, half the animals were given the COX-2 inhibitor celecoxib for the first 6 days of recovery and half were not treated. About 2 weeks later, the injured and uninjured ligaments were tested for healing strength. Celecoxib decreased ligament healing strength by 32%, the researchers said.

First Page Preview View Large
First page PDF preview
First page PDF preview