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The World in Medicine
August 8, 2001

Hemochromatosis Clue

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JAMA. 2001;286(6):663. doi:10.1001/jama.286.6.663-JWM10007-3-1

For individuals who have hereditary hemochromatosis—including about 0.5% of the US white population—buildup of iron in the body caused by aberrant iron metabolism can cause severe organ damage and other health problems. Scientists have identified hemochromatosis-related mutations in some of the genes involved in iron metabolism, but not all genes or mutations that underlie this condition are known.

Now, however, a team of researchers from the Netherlands has identified a new gene that, when mutated, can cause this relatively common disorder. The new findings were reported in the July issue of Nature Genetics.

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