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August 26, 2009

Dementia and Hypoglycemic Episodes in Patients With Type 2 Diabetes Mellitus

JAMA. 2009;302(8):843-844. doi:10.1001/jama.2009.1205

To the Editor: Dr Whitmer and colleagues1 reported a relationship between severe hypoglycemia and incident dementia in a large cohort of older people with type 2 diabetes. Although severe hypoglycemia may cause permanent cognitive impairment, the results of this study should be viewed with caution. It seems unlikely that a single episode of severe neuroglycopenia could increase the risk of dementia by 50%.

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