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January 9, 2002

Cost-effectiveness of Homocysteine-Lowering Therapy to Prevent Coronary Heart Disease

Author Affiliations

Stephen J.LurieMD, PhD, Senior Editor


Not Available


Copyright 2002 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2002American Medical Association

JAMA. 2002;287(2):190. doi:10.1001/jama.287.2.190-JLT0109-3-1

To the Editor: In their cost-effectiveness analysis of vitamin supplementation to lower homocysteine levels and prevent coronary heart disease, Dr Tice and colleagues1 did not use data from beyond February 1999. The modeling in Table 1 of their article is actually not needed, since 2 controlled total homocysteine (tHcy)–lowering treatment studies have been conducted in the United States and Canada among patients with coronary artery disease who have been chronically exposed to a background of folic acid–fortified cereal grain flour since 1999.2,3 These studies show that tHcy-lowering effects are only one third to one half of those listed by Tice et al.

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