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Medical News & Perspectives
February 20, 2002

Strep A, Neuropsychiatric Disorders Tie Found

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JAMA. 2002;287(7):828. doi:10.1001/jama.287.7.828-JMN0220-2-1

Chicago—The abrupt onset of obsessive-compulsive disorder (OCD) and tic disorders in children appears to be linked in some cases to acute streptococcal infections and may respond to prompt treatment with antibiotics, according to findings presented at the Interscience Conference on Antimicrobial Agents and Chemotherapy.

Previous research had linked a sudden appearance of neuropsychiatric symptoms (such as obsessions, compulsions, and motor or vocal tics, alone or in combination) following a strep throat infection caused by group A β-hemolytic Streptococcus (GABHS)—an association known as pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, or PANDAS.

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