Stephen J.LurieMD, PhD, Senior Editor
In Reply: In response to Dr Carr, the patients in our study were highly experienced with antiviral drugs: 100% had prior PI exposure (an entry requirement) and of these 79% had exposure to 2 or more PIs; 100% were nucleoside analog experienced; and 44% were nonnucleoside reverse transcriptase inhibitor (NNRTI) experienced. This high degree of drug experience was reflected in the baseline phenotypic drug susceptibilities. As described in our article, of 139 randomly selected patients at baseline, 19% to 66% had viral strains with 50% inhibitory concentrations of more than 2.5-fold above the reference strain for at least 1 of the 4 drugs common to all study arms.
Hammer SM, Vaida F, Bennett KK, Mellors JW. Virologic Outcomes of Complex Drug Regimens for Human Immunodeficiency Virus—Reply. JAMA. 2002;288(19):2406. doi:10.1001/jama.288.19.2406-JLT1120-3-2