Stephen J.LurieMD, PhD, Senior Editor
To the Editor: Dr Balk and colleagues1 found that randomized controlled trials (RCTs) with high scores for allocation concealment, double-blinding, and 22 other quality measures had similar results as low-quality trials, as defined by these indicators. However, the authors' ambitious efforts may have diluted the quality of some their assessments and hindered comparability with prior studies.
Schulz KF, Altman DG, Moher D. Allocation Concealment in Clinical Trials. JAMA. 2002;288(19):2406. doi:10.1001/jama.288.19.2406-JLT1120-4-1