A spontaneous mutation in a single gene called BRAF is involved in two thirds of cases of melanoma, according to new findings by an international team of researchers from the United Kingdom, Australia, the United States, Italy, and Hong Kong. The group also found that the same gene is mutated in a smaller proportion of a variety of other human malignancies, including colorectal and ovarian cancers.
Stephenson J. Melanoma Susceptibility Gene. JAMA. 2002;288(2):155. doi:10.1001/jama.288.2.155-JWM20007-2-1