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November 27, 2002

Estrogen Replacement Therapy and Risk of Ovarian Cancer in Postmenopausal Women

Author Affiliations

Stephen J.LurieMD, PhD, Senior Editor


Not Available


Copyright 2002 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2002American Medical Association

JAMA. 2002;288(20):2538. doi:10.1001/jama.288.20.2538-JLT1127-1-2

To the Editor: Dr Lacey and colleagues1 found a significantly increased risk of ovarian cancer in women who used unopposed ERT, but not ERT with progestins. We are concerned that the sample was atypical in that most had a history of suspicious breast lumps. Eighty-four percent of the person-years on which the relative risk estimates were calculated were derived from women who were recommended to have surgery or had surgery for breast lumps.

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