Stephen J.LurieMD, PhD, Senior Editor
To the Editor: Dr Lacey and colleagues1 found a significantly increased risk of ovarian cancer in women who used unopposed ERT, but not ERT with progestins. We are concerned that the sample was atypical in that most had a history of suspicious breast lumps. Eighty-four percent of the person-years on which the relative risk estimates were calculated were derived from women who were recommended to have surgery or had surgery for breast lumps.
Gilbert L, Krishnamurthy S, Tan SL, Franco EL. Estrogen Replacement Therapy and Risk of Ovarian Cancer in Postmenopausal Women. JAMA. 2002;288(20):2538. doi:10.1001/jama.288.20.2538-JLT1127-1-2