Stephen J.LurieMD, PhD, Senior Editor
In Reply: We interpret our and others' data differently than do Drs Burry and Cain. It is true that women with short-term estrogen-progestin replacement therapy did not have increased risk of ovarian cancer in our study, but there are insufficient data to adequately assess risk associated with short-term and longer-term postmenopausal estrogen plus progestin use. Our article addressed both studies that Burry and Cain mention and we explained why that meta-analysis1 provides more support for an increased risk than a null association.
Lacey, Jr JV, Mink PJ, Lubin JH, Sherman ME, Troisi R, Hartge P, Schatzkin A, Schairer C. Estrogen Replacement Therapy and Risk of Ovarian Cancer in Postmenopausal Women—Reply. JAMA. 2002;288(20):2539. doi:10.1001/jama.288.20.2539-JLT1127-1-3