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November 27, 2002

Estrogen Replacement Therapy and Risk of Ovarian Cancer in Postmenopausal Women—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior Editor


Not Available

JAMA. 2002;288(20):2539. doi:10.1001/jama.288.20.2539-JLT1127-1-3

In Reply: We interpret our and others' data differently than do Drs Burry and Cain. It is true that women with short-term estrogen-progestin replacement therapy did not have increased risk of ovarian cancer in our study, but there are insufficient data to adequately assess risk associated with short-term and longer-term postmenopausal estrogen plus progestin use. Our article addressed both studies that Burry and Cain mention and we explained why that meta-analysis1 provides more support for an increased risk than a null association.

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