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December 4, 2002

Preoperative Hand-Rubbing vs Hand-Scrubbing—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior Editor


Not Available

JAMA. 2002;288(21):2688. doi:10.1001/jama.288.21.2688-JLT1204-5-2

In Reply: Dr Sosis underscores the pitfalls of equivalence trials and raises an important issue that could have seriously flawed our conclusion, namely a lack of statistical power due to the incorrect assumption of the rate of SSI in the control group. In addition, Sosis reminds us that absence of evidence is not evidence of absence (of difference). Our trial, however, was designed to demonstrate the equivalence of hand-rubbing and traditional hand-scrubbing protocols in terms of the SSI rate. Relative to a conventional superiority trial, this choice implied an average of 10% larger sample size with specific methods of calculation.1

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