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December 11, 2002

Risks of Postmenopausal Hormone Replacement

Author Affiliations

Stephen J.LurieMD, PhD, Senior Editor


Not Available

JAMA. 2002;288(22):2821. doi:10.1001/jama.288.22.2821-JLT1211-1-6

To the Editor: The WHI trial1 was stopped early because of an increased risk of breast cancer among women receiving the estrogen-progestin combination. The age-adjusted incidence rates for breast cancer from 1988-1992 for women aged 50 to 79 years, comparable with WHI, were 24 to 47 per 10 000 person-years.2 The numbers of cases in the control and intervention group were within the normal range of healthy US women, indicating no increased risk in the intervention group.

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