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December 11, 2002

Risks of Postmenopausal Hormone Replacement

Author Affiliations

Stephen J.LurieMD, PhD, Senior Editor


Not Available

JAMA. 2002;288(22):2821. doi:10.1001/jama.288.22.2821-JLT1211-1-7

To the Editor: Although the WHI investigators first became aware of the possibility of cardiovascular harmful effects of the progestin-estrogen combination in late 1999, the data and safety monitoring board (DSMB) did not stop the trial then.1 This decision seems questionable in light of other important double-blind placebo-controlled trials published in 1998-1999, such as HERS,2 PEPI mammography results,3 and SPAF,4 all of which found evidence of potential harmful cardiovascular and premalignant effects of combined HRT.

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