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Health Agencies Update
December 18, 2002

Destructive Adenoviruses

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Copyright 2002 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2002American Medical Association

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JAMA. 2002;288(23):2959. doi:10.1001/jama.288.23.2959-JHA20012-2-1

Like a prisoner wielding metal rods to smash his way to freedom, adenoviruses can grab structural proteins inside host cells and break their way out, killing the cells in the process, say researchers at the US Department of Energy's Brookhaven National Laboratory.

"In essence, a protein in the infected cells can serve as the seed of its own destruction," said Brookhaven biologist Walter Mangel, PhD, coauthor of a report describing the finding in the November 29, 2002, Journal of Biological Chemistry.

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