Stephen J.LurieMD, PhD, Senior Editor
To the Editor: In their meta-analysis, Dr Safdar and colleagues1 concluded that antibiotic exposure during Escherichia coli O157:H7 colitis was not associated with an increased risk of hemolytic uremic syndrome (HUS). Because the included studies were very heterogeneous, however, conclusions based on a single risk estimate may be misleading.
Gill CJ, Hamer DH, Lau J. Risk of Hemolytic Uremic Syndrome From Antibiotic Treatment of Escherichia coli O157:H7 Colitis. JAMA. 2002;288(24):3110. doi:10.1001/jama.288.24.3110-JLT1225-2-1