To the Editor: The study by Dr Bell and colleagues1 described the association between tamsulosin and adverse events following cataract surgery. The authors theorized that tamsulosin may demonstrate greater receptor affinity and selectivity compared with other antagonists studied, thereby resulting in the observed selective toxicity. However, a hypothesis that tamsulosin is bound to receptors in a manner resulting in protracted selective and specific ocular toxicity is problematic.
Gaynes BI. Tamsulosin and Ophthalmic Adverse Events After Cataract Surgery. JAMA. 2009;302(10):1054-1055. doi:10.1001/jama.2009.1286