Stephen J.LurieMD, PhD, Senior Editor
In Reply: We agree with the concerns of Dr Gill and colleagues regarding the differential expression of Shiga-toxin genes. We also agree that the genetic characteristics of the infecting strain of E coli 0157:H7 are important to consider when assessing the effects of antimicrobial use on the risk of development of HUS. Their concerns would be obviated by the large multicenter RCT we advocate, with multiple strains of infecting E coli 0157:H7 represented in the study population.
Maki DG, Safdar N. Risk of Hemolytic Uremic Syndrome From Antibiotic Treatment of Escherichia coli O157:H7 Colitis—Reply. JAMA. 2002;288(24):3112. doi:10.1001/jama.288.24.3112-JLT1225-2-4