To the Editor: Dr Berger and colleagues1 conducted a meta-analysis investigating aspirin for prevention of cardiovascular events in patients with peripheral arterial disease (PAD). They found that treatment with aspirin alone or with dipyridamole in patients with PAD resulted in a statistically nonsignificant decrease in cardiovascular events and a statistically significant reduction in nonfatal stroke. Although funnel plots were reportedly generated for cardiovascular events, the authors did not assess publication bias for nonfatal stroke.
Takagi H, Umemoto T. Aspirin for Prevention of Stroke and Cardiovascular Events Among Patients With Peripheral Artery Disease. JAMA. 2009;302(11):1165-1166. doi:10.1001/jama.2009.1325