To the Editor: In their meta-analysis, Dr Risch and colleagues1 concluded that the study of gene-environment interaction in mental disorders should await the identification of “robust marginal gene associations.” We believe that this conclusion extends well beyond the data, and an alternate explanation of their findings suggests other courses of action. The absence of replicable findings across studies that assessed both direct genotype-depression associations and gene-environment interactions may be explained by mismeasurement and undermeasurement of relevant environmental contexts.
Koenen KC, Galea S. Gene-Environment Interactions and Depression. JAMA. 2009;302(17):1859-1862. doi:10.1001/jama.2009.1575