To the Editor: We have some concerns with the meta-analysis by Dr Risch and colleagues,1 which examined the role of 5-HTTLPR in moderating the relationship between stress and depression. We agree with the authors that blanket acceptance of a robust and universal interaction between 5-HTTLPR and stress is unwarranted, and it is premature to translate this into clinical and forensic settings. However, the authors concluded that the original finding was not confirmed, despite numerous independent positive reports in the literature. Other conclusions should be considered.
Lotrich FE, Lenze E. Gene-Environment Interactions and Depression. JAMA. 2009;302(17):1859-1862. doi:10.1001/jama.2009.1576