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November 4, 2009

Gene-Environment Interactions and Depression

JAMA. 2009;302(17):1859-1862. doi:10.1001/jama.2009.1578

To the Editor: Dr Risch and colleagues1 concluded that the results of a study2 showing that the serotonin transporter gene (5-HTTLPR) genotype moderates the effect of stressful life events on the risk of depression could not be replicated in a meta-analysis of 14 studies. The authors pointed out the importance of replication studies before new findings are translated into clinical and health practices. We believe that it is also important to note that editorial practices of scientific journals may contribute to the lack of attention received by studies that fail to replicate original findings.

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