November 11, 2009

Genome-wide Association Studies and Human DiseaseFrom Trickle to Flood

Author Affiliations

Author Affiliations: Department of Statistical Genetics (Dr Visscher) and Department of Molecular Epidemiology (Dr Montgomery), Queensland Institute of Medical Research, Brisbane, Australia.

JAMA. 2009;302(18):2028-2029. doi:10.1001/jama.2009.1643

Many common complex diseases such as hypertension, diabetes, coronary heart disease, psychiatric disorders, and some cancers have a genetic etiology. Despite enormous efforts over the last few decades, little real progress was made in finding the genes and causal variants involved. Genome-wide association studies, in which hundreds of thousands of DNA markers are tested (usually in a case-control design) for association with disease, provide the first effective approach to search for genetic variants that contribute to the complex etiology of common human diseases.

First Page Preview View Large
First page PDF preview
First page PDF preview