In Reply: We thank Dr Smoljanovic and colleagues for their comments regarding complications associated with BMP usage. As we noted in our article, the available data did not allow us to address the correlation between dosage of BMP and complication rate. We agree that additional work is needed to clarify the short-term and long-term complications associated with different dosages of BMP.
Cahill KS, Claus EB. Complications Associated With Use of Bone-Morphogenetic Proteins in Spinal Fusion Procedures—Reply. JAMA. 2009;302(19):2090-2091. doi:10.1001/jama.2009.1640