In Reply: Dr Basnyat's comments highlight many of the current challenges in antimicrobial therapy for patients with typhoid fever. Fluoroquinolones have been widely used; however, their effectiveness depends on the susceptibility of the patient's Salmonella ser Typhi isolate and the type of fluoroquinolone.1 Gatifloxacin, a higher-generation fluoroquinolone, may be an alternative to older fluoroquinolones for S Typhi strains with decreased ciprofloxacin susceptibility.
Lynch MF, Mintz ED. Typhoid Fever in the United States and Antibiotic Choice—Reply. JAMA. 2010;303(1):34-35. doi:10.1001/jama.2009.1936